首页|喜炎平注射液与注射用美洛西林钠配伍的稳定性考察

喜炎平注射液与注射用美洛西林钠配伍的稳定性考察

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目的:考察喜炎平注射液和注射用美洛西林钠在0.9％氯化钠注射液和5％葡萄糖注射液中的配伍稳定性.方法:观察配伍液在0h、1h、2h、4h、6h、8h内的性状,在上述时间点下测定其pH值,并采用紫外分光光度法和高效液相色谱法分别测定穿心莲内酯磺化物和美洛西林含量变化.结果:两药配伍后,8h内配伍液的性状、pH值及美洛西林含量均无显著变化,穿心莲内酯磺化物含量变化较大,不稳定.结论:喜炎平注射液与注射用美洛西林钠在0.9％氯化钠及5％葡萄糖注射液中配伍后8h内不稳定,不建议临床配伍使用.
Determination of Compatible Stability of Xiyanping Injection and Mezlocillin Sodium Injection
Objective:To observe the compatible stability of Xiyanping injection and mezlocillin sodium injection with 0.9 ％ sodium chloride injection and 5 ％ glucose injection respectively.Methods:The variations in the appearance and pH of the compatible solution were observed by eye and acidimeter separately at 0,1,2,4,6 and 8h.The content of andrographolide and mezlocillin were determined by UV spectrophotometry and HPLC respectively.Results:There were no significant changes in appearance,pH value and the content of mezlocillin sodium within eight hours,while the andrographolide contents change greatly.Conclusion The compatible solution containing Xiyanping injection and mezlocillin sodium is not stable in 0.9 ％ sodium chloride injection and 5 ％ glucose injection,and it cannot be used clinically.

XiyanpingMezlocillin sodiumStability

熊百莉、艾强、江辉

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贵阳市儿童医院,贵州贵阳550003

贵阳中医学院,贵州贵阳550002

喜炎平 美洛西林钠 稳定性

贵阳市科技局科技创新公共技术平台建设项目

筑科合同字第3-2号

2016

10.16588/j.cnki.issn1002-1108.2016.04.011

贵阳中医学院学报
贵阳中医学院

贵阳中医学院学报

影响因子：1.18
ISSN：1002-1108
年,卷(期)：2016.38(4)
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