Preliminary Safety Evaluation of the cucurbit[7]uril on Mice
Objective:To evaluate the safety pharmacology of cucurbit[7]uril on mice,in order to provide basic data for the further research on the effect of the cucurbit[n]uril on human body and the development it as new drug materials.Methods:On the basis of technology research guiding principles of traditional Chinese medicine,natural medicine and acute toxicity as well as the requirements of the OECD new released oral toxicity test method,took modified CURTIS method to calculate LD50 value of the cucurbit[7]uril.Results:The value of cucurbit[7]uril LD50 is 49.1g/kg.Conclusion:Cucurbit[7]uril is non-toxic and safe,and can be widely applied in the field of supramolecular chemistry as a new type of safety,low toxicity supramolecular drug carrier,
NETL
NSTL
万方数据
维普
