Effect of chemoembolization with drug-loaded microspheres on therapeutic effect and serum GGT,calcium and phosphorus metabolism in patients with advanced liver cancer
Objective To investigate the efficacy of chemoembolization with drug-loaded microspheres in patients diagnosed with advanced liver cancer.Methods A total of 65 patients with advanced liver cancer treated between May 2018 and January 2023,were divided into 2 groups based on the surgical method used:control group(31 cases:conventional surgery)and observation group(34 cases:drug-loaded microsphere chemoembolization).The efficacy of these two treatment approaches was compared.Results The level of glutamyltransferase(GGT)in the observation group(28.26± 2.62 U/L)was significantly lower compared to the control group(53.99±3.71 U/L).Similarly,the levels of CA19-9(6.84±0.26 U/mL)and AFP(310.87±5.52 ng/ml)were also lower in the observation group than in the control group(459.26±6.18 ng/ml)(t=32.522,P＜0.05;t value=60.674,P＜0.05;t value=102.256,P＜0.05).1 month pose-surgery,the blood concentrations of Ca(2.12±0.14 mmol/L),iPTH(179.56±19.52 pg/mL)and Ca × P product(45.86±3.62 mg2/dL)in the observation group showed a significantly decrease compared to the control group(2.20± 0.15 mmol/L,206.84±22.17 pg/mL,51.4 7±4.26 mg2/dL).Additionally,the level of blood phosphorus(1.56±0.13 mmol/L)was higher in the observation group than in the control group(1.83±0.14 mmol/L),while the product of calcium and phosphorus(45.86±3.62 mg2/dL)was lower in the observation group compared to the control group(51.47 ±4.26 mg2/dL)(t value=2.224,P＜0.05;t value=5.275,P＜0.05;t value=5.737,P＜0.05;t value=8.062,P＜0.05).Moreover,one month after the operation,the levels of ALT(44.26±3.52 U/L),AST(36.85±5.14 U/L),and Tbil(16.56±2.62)μmol/L were lower than those in the control group(53.97±4.17 U/L,48.10±6.71 U/L,21.45± 3.05 μmol/L,respectively).(t=10.174,P＜0.05;t value=7.627,P＜0.05;t value=6.951,P＜0.05).The incidence of adverse reactions between the two groups was compared(x2=0.300,P=0.584).Survival rates at 3 month(x2=0.375,P=0.540)and 6 months(x2=6.181,P=0.013)after surgery were also compared.Conclusion Chemoembolization with drug-loaded microspheres has demonstrated effectiveness in the treatment advanced liver cancer patients,with a high survival rate observed at 6 months post-surgery.This treatment approach warrants further investigation and potential application in clinical practice.
Advanced liver cancerChemoembolization with drug-loaded microspheresCalcium and phosphorus metabolism
NETL
NSTL
万方数据
