Characteristics of patients with primary biliary cholangitis-autoimmune hepatitis overlap syndrome and diverse anti-mitochondrial antibody in Qinghai region
Objective To delineate the clinical and pathological characteristics of primary biliary cholangitis-autoimmune hepatitis overlap syndrome(PBC-AIH OS)in Qinghai province,aiming to enhance clinical diagnosis and treatment protocols.Methods In a retrospective study spanning December 2017 to December 2022,85 patients diagnosed with PBC-AIH OS were analyzed.The cohort was divided into two groups based on Anti-mitochondrial antibody status:58 in Group A(positive)and 27 in Group B(negative).The study evaluated general clinical features,comorbid conditions,serum biochemical markers,immunological indices,and liver tissue pathology.Date adhering to a normal distribution were presented as c±s and analyzed using the independent sample t-test.Non-normally distributed measurements were expressed as medians(P25,P75)and compared using the Wilcoxon rank-sum test.Categorical data were analyzed using chi-square tests to compare proportions between groups;with a P-value of ＜0.05 denoting statistical significant.Results In the comparison between the two groups,there were no statistically significant differences observed interms of sex,age,TBil,γ-GGT,ALP,IgG,Ro52 presence,the detection rate of SSA,the prevalence of Sjogren's syndrome,and the grades of liver inflammation and fibrosis(P＞0.05).However,significant differences were noted in the levels of ALT(115.41± 76.63 vs.255.90±244.90)and IgM[4.05(2.75,5.43)vs.1.99(1.41,3.51)],as well as in the detection rate of ANA-G(x2=9.67)and the morbidity rate of autoimmune thyroid disease(AITD)(x2=5.74),with P＜0.05 indicating statistical significance.Conclusion Patients in Group A exhibited levels of ALT,IgM and ANA-Gr detection rates,whereas the prevalence of AITD was greater in the Group B.The pathological histology for both groups predominantly revealed moderate to severe,inflammation and fibrosis rades,suggesting an insidious onset,prolonged disease course,and advanced stage at diagnosis for these patients.Given these findings,it is advisable for patients diagnosed with PBC-AIH OS to undergo thorough screening for,thyroid disorders.
NETL
NSTL
万方数据
维普
