Clinical features and influencing factors of hepatitis B-related cirrhosis complicated by spontaneous enterococcal peritonitis
Objective To explore the clinical characteristics of hepatitis B-related cirrhosis complicated by spontaneous enterococcus peritonitis(SEP),and analyze the influencing factors of the complication.Methods From July 2018 to March 2023,120 patients were admitted with hepatitis B related cirrhosis.Among them,55 patients complicated with SEP were classified as concurrent group,and the remaining 65 patients were classified as non-concurrent group.The clinical characteristics of patients in these two groups were compared,and the risk factors of SEP in hepatitis B-related cirrhosis were analyzed.Results The proportion of gastrointestinal bleeding,previous treatment with antibiotics,and history of abdominal surgery in the concurrent group was 32.7％,85.5％,and 43.6％,respectively,which were higher than those in the non-concurrent group(12.3％,49.2％,and 7.7％);The levels of albumin and creatinine were(29.5±3.6)g/L and(95.7±9.4)respectively pmol/L,lower than the non-concurrent group[(32.9±4.3)g/L,(121.7±11.8)μmol/L,P＜0.05].By multivariate logistic regression analysis it was found that gastrointestinal bleeding,previous antimicrobial treatment,history of abdominal surgery,low albumin and low creatinine were all risk factors for SEP in hepatitis B-related cirrhosis patients(OR=4.721,4.623,5.013,5.286,5.124,P＜0.05).Conclusion The risk of SEP in hepatitis B-related cirrhosis is high,with gastrointestinal bleeding,history of antimicrobial treatment,abdominal surgery,and low levels of albumin and creatinine as the risk factors,which warrant clinical attention.
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