Predictive value of AARC-ACLF score combined with NLR in the short-term prognosis of chronic hepatitis B-related acute liver failure
Objective To investigate the predictive value of the ACLF Research Group(AARC-ACLF)score combined with the neutrophil-to-lymphocyte ratio(NLR)in assessing the short-term prognosis of hepatitis B(HBV)-related chronic acute liver failure(ACLF).Methods A total of 94 patients diagnosed with HBV-related ACLF were included in this study.Upon admission,the NLR was assessed,and the AARC-ACLF score was calculated within 24 hours.Based on clinical efficacy and survival outcomes,patients were divided into a favorable prognosis group and an unfavorable prognosis group for further analysis of factors influencing disease progression in HBV-related ACLF.The predictive capacity of the AARC-ACLF score and serum NLR level on the prognosis of HBV-related ACLF was assessed.Results Among the 94 participants,58 showed a favorable prognosis,while 36 exhibited an unfavorable prognosis.In the unfavorable prognosis group,the prothrombin time(PT),total bilirubin(TBIL),white blood cell count(WBC),NLR,and AARC-ACLF score were significantly higher[(26.68±6.91)s,(330.2±126.4)μmol/L,(6.67±2.06)× 109/L,(6.45±2.76),and(10.14±1.29)points,respectively]compared to those in the favorable prognosis group[(20.32±4.20)s,(180.1±83.7)μmol/L,(5.06±1.97)× 109/L,(2.85±1.67),and(8.03±1.09)points;P＜0.05].Elevated NLR and AARC-ACLF scores were identified as significant indicators of poor prognosis among HBV-related ACLF patients(P＜0.05).The AUC values for predicting prognosis using serum NLR level,AARC-ACLF score,and the combination of NLR with AARC-ACLF score in HBV-related ACLF patients were 0.878,0.892,and 0.943,respectively.Conclusion Higher serum NLR levels and AARC-ACLF scores in HBV-related ACLF patients suggest their potential as valuable clinical predictors for short-term prognosis.Combining both factors can enhance the predictive power significantly.
ACLF research group score of the Asia-Pacific association for liver researchNeutrophil to lymphocyte ratioChronic hepatitis B-related acute liver failurePrognosis
万方数据
维普
