Clinical characteristics of patients with recurrent chronic drug-induced liver injury:an analytical study
Objective To analyze the clinical characteristics of patients with recurrent chronic drug-induced liver injury.Methods A retrospective analysis was conducted on the clinical data of 265 patients with chronic drug-induced liver injury who were admitted to our hospital between March 2020 and March 2023.After a one-year follow-up,patients were categorized into two groups:a recurrent group(n=33)and a non-recurrent group(n=232),based on the presentce of recurrence.The study compared general informaion,laboratory examination indicators,and liver histological characteristics between the two groups to identify the clinical features associated with the recurrence of chronic drug-induced liver injury.Multivariate logistic regression was employed to analyze high-risk factors for recurrence.Results The mean ages of the recurrent and non-recurrent groups were 44.2±7.9 years and 40.8±7.5 years,respectively,with the difference being statistically significant(P＜0.05).The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBil),γ-glutamyltranspeptidase(GGT),and prothrombin time(PT)in the recurrence group were 89.4±13.2 U/L,87.2±12.5 U/L,47.3±6.3 μmol/L,105.4±15.4 U/L and 14.2±2.7 s.respectively.These are significantly higher compared to the non-recurrent group,which had ALT,AST,TBil,GGT.And PT values of 37.5±7.1 U/L,32.3±7.0 U/L,15.2±2.0 µmol/L,45.3±8.5 U/L and 12.6±2.3 s,respectively(P＜0.05).Additionally,the recurrent group exhibited more severe liver inflammation and fibrosis,with rates of 75.8％and 36.3％,compared to 9.9％and 23.7％in the non-recurrent groups,respectively(P＜0.05).Multivariate logistic regression analysis identified age,AST,TBil,GGT,PT,cholinesterase,degree of inflammation,and degree of fibrosis as significant risk factors for the recurrence of chronic drug-induced liver injury(OR=5.068,4.909,4.993,4.604,4.688,4.531,4.627,5.023,P＜0.05).Conclusion When chronic drug-induced liver injury recurs,patients typically present with advanced age,abnormal laboratory findings,and more severe liver inflammation,and fibrosis.This high-risk group warrants careful clinical attention.
Chronic drug-induced liver injuryRecurrence of the conditionClinical features
万方数据
维普
