Clinical study of dulaglutide combined with a ketogenic diet in the treatment of elderly patients with type 2 diabetes mellitus complicated by non-alcoholic fatty liver disease
Objective To evaluate the therapeutic effects of dulaglutide in combination with a ketogenic diet in the management of elderly patients with type 2 diabetes mellitus(T2DM)complicated with non-alcoholic fatty liver disease(NAFLD).Methods From February 2021 to February 2023,94 patients with T2DM and NAFLD were enrolled in this study.Participants were randomly assigned to two groups:by random draw,the control group(n=47),receiving insulin and a ketogenic diet,and the observation group(n=47),treated with dulaglutide and a ketogenic diet.Clinical efficacy was assessed by comparing pre-and post-treatment levels of blood glucose,lipids,liver function,and oxidative stress markers between the two groups.Additionally,the incidence of adverse reactions was monitored.Results Post-treatment,the efficacy rate in the observation group was 97.87％,significantly higher than in the control group(82.98％).The observation group demonstrated significantly lower levels of fasting blood glucose(FBG)(6.10±1.22),2-hour postprandial blood glucose(2hPBG)(8.21±1.75),and HbA1c(6.21±1.25)compared to the control group(7.35±1.58,10.23±2.06,7.69±1.58,respectively).Lipid levels,including total cholesterol(TC)(3.22±0.87)and TG(1.22±0.21)were also lower in the observation group compared to the control group(4.69±1.01 and 2.15±0.57,respectively).Liver function markers such as AST(23.54±3.59),ALT(41.32±4.76),and GGT(31.62±4.01)were significantly reduced in the observation group compared to the control group(32.78±4.27,52.36±6.02,and 49.86±5.75,respectively).Additionally,oxidative stress markers,including MDA(642.51±90.27)and 8-iso-PGF2α(125.35±11.05),were lower,while GSH-Px(151.21±15.67)was higher in the observation group compared to the control group(724.25±95.21,142.58±11.47,and 120.52±12.58,respectively),with all differences being statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of dulaglutide and a ketogenic diet significantly improves clinical outcomes in elderly patients with T2DM and NAFLD,effectively reducing blood sugar and lipid levels,enhancing liver function,and mitigating oxidative stress responses compared to insulin combined with a ketogenic diet,while maintaining a comparable safety profile.
DulaglutideKetogenic dietElderly type 2 diabetes mellitusNon-alcoholic fatty liver disease
万方数据
维普
