Progress in Synthetic Methods and Biological Activities of Pregnenolone D-ring Structural Modifications
The structure of steroids and their wide range of applications in medicine are briefly described.Firstly,it is elaborated that 16-dehydropregnenolone acetate(16-DPA)occupies an important position in steroid synthesis as a key intermediate in the synthesis of steroid drugs.Subsequently,the synthetic methods of modifying the D-ring of 16-DPA with different groups to obtain steroid derivatives are reviewed in detail,including N-heterocyclic(oxazole,pyrazole,pyrimidine,and imidazole),O-heterocyclic,carbocyclic,and other modifications.As well as their displayed biological activities such as anti-tumor and anti-inflammatory are analyzed.Finally,it is summarized and its development trend and application prospects are outlooked.
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