Preparation and Performance of HA@Ag@ZIF-8@BG Degradable Scaffolds with Three-dimensional Pore Structure
Bioactive glass(BG)scaffolds were prepared by 3D printing technology,and pure BG scaffolds were obtained by sintering at 1150℃.HA@Ag@ZIF-8@BG scaffolds with different components were successfully prepared using metal organic framework(ZIF-8),silver nitrate,and hyaluronic acid(HA)as raw materials by in situ growth and dual-solvent method.The microstructure and properties of the materials were investigated using Zeta,BET,XRD,FT-IR and SEM.The porosity,compressive strength,and degradability of each component scaffold were investigated.The results showed that in situ growth did not change the original three-dimensional pore structure and porosity of the BG scaffold.The compressive strength of the scaffolds is still in the range of the mechanical strength of human cancellous bone.As the addition of ZIF-8,Ag+ and HA slowed down the degradation of the scaffold within 14 days,the degradation rate was maintained at a low rate of about 8.5%and the weak alkaline environment for cell survival was not affected,which could promote the growth of cells and new bone tissue.
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