Progress in Dipeptidyl Peptidase-Ⅳ Organic Small Molecule Fluorescent Probes
An essential transmembrane glycoprotein hydrolase,dipeptidyl peptidase-Ⅳ(DPP-Ⅳ)is intimately associated with a number of physiological functions and illnesses.Current research on biological enzyme detection is focused on organic small-molecule fluorescent probes,which have been published one after another for the detection of DPP-Ⅳ.For the first time,three types of organic small molecule fluorescent probes used for in vitro and in vivo detection and imaging of DPP-Ⅳ,namely,non-near-infrared fluorescent probes(λem<650 nm),near-infrared fluorescent probes(λem>650 nm),and two-photon fluorescent probes,were reviewed,and the design principles,structural features,and bioapplications of the three types of probes were compared and summarized,as well as their diagnostic applications in the diagnosis of DPP-Ⅳ-related diseases.Its application in the diagnosis of DPP-Ⅳ-related diseases,and discusses the challenges of DPP-Ⅳ activity detection in the future development direction.
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