二肽基肽酶-Ⅳ有机小分子荧光探针的研究进展
Progress in Dipeptidyl Peptidase-Ⅳ Organic Small Molecule Fluorescent Probes
杨政敏 1钟甜甜 2胡先运 1韩忠耀 1覃江克2
作者信息
- 1. 黔南民族医学高等专科学校,贵州 都匀 558003
- 2. 广西师范大学 化学与药学学院,广西 桂林 5410004
- 折叠
摘要
二肽基肽酶-Ⅳ(DPP-Ⅳ)是一种重要的跨膜糖蛋白水解酶,与各种生理过程和疾病密切相关,检测DPP-Ⅳ的有机小分子荧光探针被相继报道,是当前研究生物酶检测的热点.首次综述了用于DPP-Ⅳ体外和体内检测及成像的 3 类有机小分子荧光探针,分别是非近红外荧光探针(λem<650 nm)、近红外荧光探针(λem>650 nm)和双光子荧光探针,对比并总结了三种探针的设计原理、结构特点、生物应用情况及其在DPP-Ⅳ相关疾病诊断中的应用,并探讨了DPP-Ⅳ活性检测在未来发展方向上所面临的挑战.
Abstract
An essential transmembrane glycoprotein hydrolase,dipeptidyl peptidase-Ⅳ(DPP-Ⅳ)is intimately associated with a number of physiological functions and illnesses.Current research on biological enzyme detection is focused on organic small-molecule fluorescent probes,which have been published one after another for the detection of DPP-Ⅳ.For the first time,three types of organic small molecule fluorescent probes used for in vitro and in vivo detection and imaging of DPP-Ⅳ,namely,non-near-infrared fluorescent probes(λem<650 nm),near-infrared fluorescent probes(λem>650 nm),and two-photon fluorescent probes,were reviewed,and the design principles,structural features,and bioapplications of the three types of probes were compared and summarized,as well as their diagnostic applications in the diagnosis of DPP-Ⅳ-related diseases.Its application in the diagnosis of DPP-Ⅳ-related diseases,and discusses the challenges of DPP-Ⅳ activity detection in the future development direction.
关键词
二肽基肽酶-Ⅳ/荧光探针/有机小分子/生物成像/研究进展Key words
dipeptidyl peptidase IV/fluorescent probe/small organic molecule/bioimaging/research progress引用本文复制引用
基金项目
国家自然科学基金(81860317)
贵州省卫生健康委科学基金(zwkj2021-453)
黔南民族医学高等专科学校项目(Qnyz2021001)
黔南民族医学高等专科学校项目(Qnyz2023001)
出版年
2024
国家科技期刊平台
NSTL
万方数据