首页|葛根素治疗2型糖尿病及其并发症的研究进展

葛根素治疗2型糖尿病及其并发症的研究进展

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2型糖尿病(type 2 diabetes mellitus，T2DM)是常见的慢性代谢性疾病，其特征是高血糖和胰岛素抵抗，常伴随严重的并发症，致死率和致残率逐年增高。使用常规降糖药多伴有不良反应，如二甲双胍会引起呕吐、腹泻等胃肠道反应，寻找毒副作用小的"降糖"药是亟待解决的社会重大公共健康问题。传统中医药治疗T2DM有独特优势，安全有效。葛根素是中药葛根的主要活性成分，现代药理学研究和临床案例发现，葛根素在T2DM及其并发症的治疗过程中展现出良好的治疗效果。本文对葛根素治疗T2DM及其并发症的作用机制进行综述，丰富葛根素治疗糖尿病的理论依据，以期推动降糖新药研发。
Research Progress of Puerarin in Treatment of Type 2 Diabetes and its Complications
Type 2 diabetes mellitus(T2DM)is a common chronic metabolic disease characterized by hy-perglycemia and insulin resistance.It is often accompanied by serious complications,and the mortality and disa-bility rate increase year by year.Conventional hypoglycemic drugs are often accompanied by serious adverse re-actions,such as metformin,which can cause gastrointestinal reactions such as vomiting and diarrhea.To search for effective Chinese medicine to"reduce glucose"is a major public health issue that needs to be solved urgent-ly.Traditional Chinese medicine has unique advantages in treating T2DM,which is safe and effective.Puerarin is the main active ingredient of Pueraria lobata(Willd.)Ohwi.Modern pharmacological research and clinical cases found that puerarin has a significant therapeutic effect on the treatment of T2DM and its complications.In this article,the mechanism of puerarin in treating T2DM and its complications was reviewed to enrich the theo-retical basis of puerarin in treating diabetes,in order to promote the research and development of new hypogly-cemic drugs.

PuerarinPueraria lobata(Willd.)OhwiType 2 Diabetes MellitusDiabetes ComplicationsHyperglycemiaInsulin ResistanceMechanismLiterature Review

苏清雅、张鑫、廖琪欣、程龙

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中国医科大学中药与生药教研室,辽宁沈阳 110122

葛根素 葛根 2型糖尿病 糖尿病并发症 高血糖 胰岛素抵抗 作用机制 综述

辽宁省博士科研启动基金辽宁省大学生创新创业训练计划(2023)

2023-BS-093202310159022

2024

10.16588/j.cnki.issn2096-8426.2024.02.013

贵州中医药大学学报

贵州中医药大学学报

ISSN：
年,卷(期)：2024.46(2)
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