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白癜风发病机制及中医治疗进展

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白癜风(vitiligo)是一种常见的获得性色素障碍性皮肤病,以皮肤出现边界清楚、形状大小不一的脱色素斑为主要特征。本病发病机制至今未明确,现代医学认为本病的发生是遗传、自身免疫、黑色素细胞自毁、氧化应激等相互作用的结果;中医学认为白癜风的发生与脏腑功能失调、外感六淫密切相关。目前西医多以口服或外用药物、光疗及手术等治疗本病,短期疗效显著,但易反复且有诸多不良反应。中医在治疗上多以补肝肾、祛风湿、疏肝气、化瘀血为总原则,历代医家研制了大量经典名方至今沿用,疗效得到医患的一致认可。本文对近些年白癜风发病机制及中医药治疗的相关研究进展作一简要综述,以期为后续开展中医药治疗白癜风相关研究提供参考与借鉴。
Pathogenesis of Vitiligo and Progress of its TCM Treatment
Vitiligo is a common skin disease with dyschromatosis,which is characterized by different shaped and sized depigmented spots with clear boundaries.The pathogenesis of this disease is still unclear.Modern medicine believes that the occurrence of this disease is the result of the interaction of heredity,autoimmunity,melanocyte self-destruction and oxidative stress.While the traditional Chinese medicine believes that the occur-rence of vitiligo is closely related to visceral dysfunction,external contraction,and six climactic pathogens.At present,western medicine mostly uses oral or topical drugs,phototherapy and surgery to treat this disease,with obvious short-term curative effect,but it is easy to repeat and has many adverse reactions.While treating with traditional Chinese medicine,the general principles are nourishing liver and kidney,expelling wind and damp-ness,soothing liver qi and removing blood stasis.A large number of classic famous prescriptions have been de-veloped by doctors in the past dynasties,and are still in use today,and their curative effect has been recognized by doctors and patients.In this paper,the pathogenesis of vitiligo and the relevant research progress of tradition-al Chinese medicine treatment in recent years were briefly reviewed,in order to provide reference for the follow-up research on vitiligo treatment with traditional Chinese medicine.

vitiligotraditional Chinese medicinepathogenesistreatment progress

张雪莹、孟乐乐、李爽、冉晓蓉、文昌晖

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贵州中医药大学,贵州贵阳 550025

贵州中医药大学第一附属医院皮肤科,贵州贵阳 550001

白癜风 中医药 发病机制 治疗进展

国家自然科学基金

8216150685

2024

贵州中医药大学学报

贵州中医药大学学报

ISSN:
年,卷(期):2024.46(3)
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