Wnt/β-catenin信号通路在心肌纤维化中的作用研究进展
Research progress on the role of Wnt/β-catenin signaling pathway in myocardial fibrosis
高雅婷 1邱对鑫 1高磊 2石开虎1
作者信息
- 1. 南京中医药大学附属中西医结合医院(江苏南京 210028)
- 2. 南京中医药大学,中医学院·中西医结合学院(江苏南京 210023)
- 折叠
摘要
Wnt/β-catenin信号通路是一种在胚胎发育,细胞增殖分化、迁移,干细胞更新等中起关键作用的蛋白质家族.Wnt/β-catenin信号通路的失调常常会导致各种严重的疾病,例如肿瘤、心脏疾病、肺部疾病、肝脏疾病、骨骼疾病、神经疾病等.大量研究表明,Wnt/β-catenin信号通路在心肌纤维化发病机制中起重要作用,本文结合最新研究成果,从心肌纤维化相关疾病的角度对Wnt/β-catenin通路进行综述,为预防心肌纤维化提供新的思路,进一步达到防治心血管疾病的目的.
Abstract
The Wnt/β-catenin signaling pathway is a family of proteins that play a key role in embryonic development,cell proliferation and differentiation,migration,stem cell renewal,etc.Dysfunctions of Wnt/β-catenin signaling pathway often lead to various serious diseases,such as tumor,heart,lung,liver,bone and neurological diseases,etc.Numerous studies have shown that the Wnt/β-catenin signaling pathway plays an important role in the pathogenesis of cardiac fibrosis.This article,in combination with the latest research findings,presents a review of the Wnt/β-catenin pathway from the perspective of myocardial fibrosis-related diseases,in order to provide new ideas for preventing myocardial fibrosis and achieving the goal of combating cardiovascular disease.
关键词
Wnt/β-catenin/心肌纤维化/心血管疾病Key words
Wnt/β-catenin/myocardial fibrosis/cardiovascular disease引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据