Objective To evaluate the prognostic significance of a group of clinical indices in the patients with internal carotid artery occlusion(ICAO).Methods From 2017 to 2022,a total of 131 patients with ICAO were enrolled.All eligible patients were divided into acute ICAO(AICAO)and chronic ICAO groups(CICAO),which were subdivided into good and poor prognosis groups.A respective analysis was performed to identify a practical profile for the outcome prediction of the patients with ICAO.Results The overall prognosis of CIACO was good.The proportion of NIHSS score<6 in AICAO group with good prognosis and good collateral circulation compensation was significantly higher than that in poor prognosis group,while bleeding conversion was lower than that in poor prognosis group,with statistical significance(P<0.05).Dichotomous logistic regression analysis showed that the prognostic effects of NIHSS score,collateral circulatory compensation score,interventional initiation,hemorrhagic transformation,and subtotal occlusion on the prognosis of AICAO were statistically significant.There were no significant differences in basic information,past medical history,interventional operation between the two groups(P>0.05).Conclusions The patients with CICAO have a better prognosis than those with AICAO.NIHSS score<6,good collateral circulation and no-hemorrhagic transformation may have strong prognostic relevance to ICAO.High NIHSS score,poor collateral circulation and hemorrhagic transformation at the time of onset are risk factors for poor prognosis of ACAO.