Objective By analyzing the population pharmacokinetics of olanzapine,the factors affecting the pharmacokinetic parameters of olanzapine were discussed,so as to provide a basis for the clinical formulation of individualized dosing regimens.Methods In Chinese and English databases such as CNKI,Wanfang,Wipro database,FMRS,PubMed and Embase,all studies on population pharmacokinetics of olanzapine from the establishment of the database to May 2023 were searched with"olanzapine pamoate""olanzapine","population pharmacokinetics","pharmacokinetic model","nonlinear mixed-effect"and"NONMEM"as key words.Results A total of 14 population pharmacokinetic studies of olanzapine were included.Most studies described the pharmacokinetics of olanzapine as a single-chamber model.Adult pharmacokinetic model population typical values absorption rate constant was(0.3-2.85)/h;apparent distribution clearance was(10.4-25.4)L/h;apparent volume of distribution was(223-2390)L.absorption rate constants of the population of children and adolescents was(0.142-0.758)/h,apparent distribution clearance was(13.6-16.8)L/h,apparent volume of distribution was(322-899)L.Age,weight,gender,ethnicity,smoking status and concomitant medication were significant covariates affecting the pharmacokinetic parameters of olanzapine.Conclusions Estimates of pharmacokinetic parameters of olanzapine vary and have varying degrees of inter-individual variation.In the future,research should focus on special populations.Externally validation of previously published models should also be performed to more accurately describe the applicability of the models.
维普
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