广州医药2024,Vol.55Issue(6) :633-637.DOI:10.3969/j.issn.1000-8535.2024.06.010

1137例男性HPV基因分型感染情况分析

Analysis of infection status of human papillomavirus genotypes in 1 137 males

郑珊婉 李雯 杜洪
广州医药2024,Vol.55Issue(6) :633-637.DOI:10.3969/j.issn.1000-8535.2024.06.010

1137例男性HPV基因分型感染情况分析

Analysis of infection status of human papillomavirus genotypes in 1 137 males

郑珊婉 1李雯 1杜洪1
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作者信息

  • 1. 华南理工大学附属第二医院(广州市第一人民医院)病理科(广东广州 510180)
  • 折叠

摘要

目的 探讨男性人乳头瘤病毒(HPV)基因分型感染情况.方法 收集采用聚合酶链式反应反向斑点杂交法进行28种HPV基因分型检测的1 137例男性检查结果,进行回顾性分析.结果 1 137例男性患者中阳性441例,阳性率为38.79%,感染率居前5位的亚型依次为HPV6(11.35%)、HPV11(7.92%)、HPV16(5.10%)、HPV52(3.52%)、HPV43(2.64%);就诊人群以20~39岁为主,感染人数也最多,各年龄组间阳性率比较差异无统计学意义(P>0.05),≥50岁组HPV52型阳性率高于20~29岁组(P<0.05)和30~39岁组(P<0.05).单一感染占67.35%,多重感染占32.65%,单一感染中低危型占比最多(41.27%),多重感染中,二重感染占比最多(19.50%),高低危混合感染为各种类型感染之首(15.87%).结论 1 137例样本中HPV阳性率为38.79%,感染亚型以HPV6、HPV11、HPV16、HPV52、HPV43为主,单一低危型感染较为常见,各年龄组间阳性率相近.

Abstract

Objective To investigate the genotypes of human papillomavirus(HPV)infection.Methods A total of 1 137 male patients'diagnoses were collected and analyzed retrospectively,which came from the detections using polymerase chain reaction reverse dot blot hybridization to genotype 28 HPV.Results Among 1 137 male patients,441 were HPV positive,with a positive rate of 38.79%,the infections of top five HPV types were HPV6(11.35%),HPV11(7.92%),HPV16(5.10%),HPV52(3.52%),HPV43(2.64%).The majority of the patients were the 20-39 age group,and the number of infections was also the highest.There was no statistical significance on the difference in the positive rate among different age groups(P>0.05).The positive rate of HPV52 in≥50 years old group was higher than the groups of aged 20~29(P<0.05)and 30~39(P<0.05).The single and multiple infections accounted for 67.35%and 32.65%.The low-risk HPV accounted for the highest proportion(41.27%)in single infections,while in patients with multiple infections,the proportion of dual infections was the largest(19.50%)and the high-and low-risk HPV mixed infections was the maximum of the infection types(15.87%).Conclusions The detection rate of positive HPV in 1 137 male patients was 38.79%,mainly were type 6,type 11,type 16,type 52 and type 43,and the single low-risk HPV infected was common.Positive rates were similar among different age groups.

关键词

男性/人乳头瘤病毒/基因分型/感染

Key words

male/human papillomavirus/genotypes/infection

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出版年

2024
广州医药
广州市第一人民医院

广州医药

影响因子:0.811
ISSN:1000-8535
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