Objective To observe the effect of nutritional guidance combined with preventive nursing on the prevention of epilepsy accidents in children.Methods A total of 116 cases of pediatric epilepsy admitted in Jiaozuo Maternal and Child Health Care Hospital from January 2021 to January 2023 were selected.They were divided into two groups according to the nursing method,with 58 cases in each group.The control group was given usual care,while the combined group was given nutritional guidance combined preventive nursing intervention.The satisfaction,the compliance rate and MoCA score were compared between two groups.Results After nursing intervention,the satisfaction rate of the combined group was 98.28%,and the compliance rate of the combined group was 96.55%,which were higher than 87.93%and 82.76%in the control group(P<0.05).Within three months from hospitalization to discharge,compared with the control group,number of injuries,duration and frequency of seizures were less in the combined group(P<0.05).After nursing,the MoCA score of the combined group was higher than that of the control group(P<0.05).Conclusions The combined application of nutritional guidance and preventive nursing in the prevention of pediatric epileptic accidents can improve the compliance behavior of children,optimize the prevention effect of pediatric epileptic accidents,reduce the incidence of trauma and epilepsy in children,shorten the duration of illness,and improve the quality of life of children and family satisfaction.