摘要
目的 探讨富血小板血浆(PRP)联合关节镜治疗Ⅲ度半月板损伤患者的临床疗效,及其对膝关节功能恢复时间的影响.方法 选取2021年2月—2022年2月南方医科大学南方医院增城院区骨科收治的Ⅲ度半月板损伤患者45例,采用随机数字法分为观察组22例与对照组23例,对照组患者在关节镜下行半月板成形术,观察组在对照组基础上给予PRP治疗.观察两组患者术后恢复时间、治疗效果及并发症发生情况;比较两组治疗前和治疗后1、3、6个月膝关节功能、疼痛情况.结果 利用观察组患者自体全血制备的PRP,其血小板的回收率、红细胞留存率、白细胞留存率分别为(91.00±9.27)%、(0.29±0.12)%、(29.98±6.68)%,PRP制备质量稳定、可控.观察组联合PRP治疗术与关节镜手术治疗后恢复时间均短于对照组,观察组治疗有效率高于对照组(P＜0.05).经重复方差测量分析,两组美国特种外科医院膝关节评分系统(HSS)评分、西安大略大学和麦克马斯特大学骨关节炎指数(WOMAC)评分、视觉模拟疼痛评分法(VAS)交互(F交互=1.869、F交互=1.482、F交互=2.193)比较差异均有统计学意义(P＜0.05);与对照组治疗后1、3、6个月比较,观察组HSS评分升高,WOMAC评分、VAS评分下降(P＜0.05);观察组并发症总发生率4.55%低于对照组30.43%(χ2=5.156、P=0.023).结论 对于Ⅲ度半月板损伤患者,采用PRP联合关节镜手术治疗可帮助患者消炎止痛、加快疗效、加快膝关节功能的恢复,缩短其恢复的时间,效果良好,且安全性较高.
Abstract
Objective To investigate the clinical effect of platelet rich plasma(PRP)combined with arthroscopy treatment on patients with third degree meniscus injury,and its impact on the recovery time of knee joint function.Methods From February 2021 to February 2022,45 patients with Ⅲ-degree meniscal injuries admitted to the Department of Orthopedics,Zengcheng district,Nanfang Hospital of Southern Medical University were selected and divided into an observation group of 22 cases and a control group of 23 cases using the random number method.Patients in the control group received menisplasty under arthroscopy,and the observation group was given PRP treatment on the basis of the control group.The postoperative recovery time,treatment effects and complications of the two groups of patients were observed;the knee joint function and pain of the two groups before treatment and 1,3,and 6 months after treatment were compared.Results The platelet recovery rate,red blood cell retention rate,and white blood cell retention rate of PRP prepared from the autologous whole blood of patients in the observation group were(91.00±9.27)％,(0.29±0.12)％,and(29.98±6.68)％respectively.The PRP preparation quality is stable and controllable.The recovery time after combined PRP treatment and arthroscopic surgery in the observation group was shorter than that in the control group,and the treatment effectiveness of the observation group was higher than that of the control group(P<0.05).After repeated measures of variance analysis,the comparison of American Hospital for Special Surgery(HSS)Knee Scoring System,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),and visual analogue pain scales(VAS)interacted(FInteraction=1.869,Finteraction=1.482,Finteraction=2.193),the differences were statistically significant(P<0.05).Compared with the control group 1,3,and 6 months after treatment,the HSS score of the observation group increased,and the WOMAC score,VAS score decreased(P<0.05);the total incidence of complications in the observation group was 4.55％,lower than that in the control group(30.43％,χ2=5.156,P=0.023).Conclusions For patients with Ⅲ-degree meniscal injuries,PRP combined with arthroscopic surgery can help reduce inflammation and pain,speed up the curative effect,accelerate the recovery of knee joint function,and shorten the recovery time.It has good effects and is relatively safe.
维普
万方数据