Objective To explore the influence of the interaction of high uric acid(UA)and obesity on the prevalence of non-alcoholic fatty liver disease(NAFLD).Methods Using a case-control study method,504 people who underwent routine health checkups at the health checkup centre of a hospital in Lanzhou City from January 2021 to December 2021 were enrolled in the study,and 187 people were included in the NAFLD group and 317 people in the non-NAFLD group according to the diagnostic criteria.Logistic regression models,multiplicative and additive interaction models were used to investigate the factors affecting the risk factors of NAFLD and the interaction between the factors.Results Multifactorial conditional logistic regression analysis showed that the risk of NAFLD was increased in obese(OR=4.87,95%CI:3.01-7.89),diabetic patients(OR=3.40,95%CI:1.51-7.68),Helicobacter pylori(Hp)carriers(OR=1.62,95%CI:1.03-2.57);the increased risk of NAFLD prevalence in hyperuricaemia patients was 4.87,3.40,1.62,and 2.28 times higher than that of normal,non-diabetic,non-Hp carriers,and non-hyperuricemic individuals,respectively.And the adjusted interaction showed a multiplicative interaction of hyperuricaemia and obesity on the prevalence of NAFLD after controlling for the confounders(OR=0.30,95%CI:0.10-0.88,P=0.029),but no additive interaction(relative excess risk due to interaction=3.15,attributable proportion due to interaction=0.24,and synergy index=1.34)interactions.Conclusions BMI,diabetes mellitus,and Hp were independent risk factors for the prevalence of NAFLD,with hyperuricaemia and overweight and obesity having multiplicative interaction and no additive interaction.
关键词
高尿酸血症/肥胖/交互作用/病例对照研究
Key words
hyperuricemia/obesity/interaction/case control study
维普
万方数据