Objective To explore the correlation between depression and comorbidity in elderly patients with cerebral infarction.Methods A total of 80 elderly patients treated from September 2021 to July 2023 were selected.The patients were evaluated using the Geriatric Depression Scale(GDS),patients were divided into the non-depression group(n=39,GDS≤10 points)and the depression group(n=41,GDS>10 points),and they were divided into different subgroups(such as concurrent digestive disorders,concurrent circulatory disorders,etc.).Comparing the differences in patient proportions in different subgroups,and the correlation between the GDS score and its Charlson comorbidity index(CCI)score in 80 elderly patients with cerebral infarction was analyzed with Pearson correlation analysis.Results The proportion of depression in 80 patients was 51.25%,showing a significantly higher incidence of depression in elderly patients with a comorbid circulatory system,endocrine system and motor system disease(P<0.05);Pearson correlation analysis showed that GDS score in elderly patients with a cerebral infarction was positively correlated with their CCI score(r=0.180,P<0.001).Conclusions The incidence of depression in elderly patients with cerebral infarction is relatively high,and more attention should be paid to elderly patients with concurrent circulatory system diseases,endocrine system diseases and motor system diseases to prevent the occurrence of depression.