Objective To analyze the structural changes and influencing factors of the hospitalization expenses for patients with cerebral infarction in a tertiary general hospital in Guangzhou,and provide a scientific basis for reducing economic burden of the patients.Methods The front page data of medical records with the main diagnosis of I63 were collected in the sample hospital.Descriptive statistics analysis of hospitalization expenses structure and multiple linear regression analysis of the influencing factors were carried out by SPSS 20.0.Results The annual growth rate of average hospitalization expenses of cerebral infarction patients from 2015 to 2022 in the sample hospital was 2.86%per year.The highest proportion of hospitalization expenses was medicine fee,the proportion of which declined year by year with a minimum 27.74%in 2022.The proportion of technical labor costs accelerated year by year with a maximum 47.41%in 2022.This study revealed the main factors influencing hospitalization expenses were hospital internal infection or not,length of stay,payment method and so on(F=990.10,P<0.001).Conclusions The structure of hospitalization expenses for cerebral infarction patients was significantly optimized,but the economic burden of patients was still heavy affected by a combination of factors.In order to minimize the burden of patients,hospitals should improve medical quality and service efficiency and implement clinical pathway management strictly,to reduce unnecessary inspections and consumables.