Objective To investigate the effect of 131Ⅰ on Graves'disease(GD)in children and young adults and its influencing factors.Methods The clinical data of GD patients aged≤22 who received 131Ⅰ treatment in Nuclear Medicine Department of Jianyang People's Hospital from 2013 to 2022 were retrospectively analyzed.The planned dosage of 131Ⅰ was 80～140 μCi per gram of thyroid tissue,and the dosage of 131Ⅰ was determined according to the iodine uptake rate and thyroid mass.According to the thyroid function indicators of 3 to 6 months after 131Ⅰ treatment,the curative effect was evaluated,and the thyroid function returned to normal or hypothyroidism occurred were considered as cured.The clinical characteristic parameters of the cured group and the non-cured group were analyzed to evaluate the factors that might affect the curative effect.Results Seventy-one patients were included:23 males and 48 females,aged 11-22.The thyroid mass of the children ranged from 4.8 to 60.0 g,with an average of 22.1 g.The dosage of 131Ⅰ ranges from 6 to 24 mCi,with an average of 11.3 mCi.Forty-nine patients(69%)were cured and 22(31%)were not cured.Univariate analysis showed that there were no significant differences in age,sex,titer of thyrotropin receptor antibody,thyroid iodine uptake rate,thyroid mass and 131Ⅰ dosage between the cured group and the non-cured group(all P＞0.05).Conclusions With the planned dosage of 80～140 μCi per gram of thyroid tissue,the efficacy of 131Ⅰ in the treatment of GD in children and young adults can reach 69%.
关键词
格雷夫斯病/儿童青年/131Ⅰ/疗效
Key words
Graves'disease/children and adolescent/131Ⅰ/outcome
万方数据