Objective To summarize the clinical manifestations,endoscopic and pathological features,treatment and prognosis of eosinophilic gastroenteritis(EG)in children.Methods A retrospective analysis was carried out on clinical data of 48 patients with EG diagnosed at the Department of Pediatrics of Binzhou Medical University Hospital from January 2019 to December 2022,including clinical symptoms,laboratory examination,imaging examination,endoscopic and pathological examination,treatment and follow-up.Results A total of 48 patients were included in the analysis,including 26 males(54.17%)and 22 females(45.83%),with the median age of 7.8 years(7 months to 13 years).Twenty patients(41.67%)had a history or family history of allergy.The most clinical symptoms were abdominal pain(34 cases,70.83%),diarrhea(18 cases,37.5%)and abdominal distension(12 cases,25%).Peripheral blood eosinophils(EOS)increased in 36 cases(75%),and the serum total IgE increased in 14 cases(29.17%).48 cases underwent gastroscopy,the most common manifestations were mucosal hyperemia and edema(32 cases,66.67%),punctate erythema(28 cases,58.33%)and erosion(22 cases,45.83%).Twenty-eight cases underwent colonoscopy,the manifestations were mucosal hyperemia and edema(18 cases,64.29%),spotted erythema(15 cases,53.57%)and nodular eminence(12 cases,42.86%).Mucosal histopathology showed a large number of EOS infiltration,mainly involving the descending duodenum,gastric antrum and terminal ileum.All children were treated with dietary intervention,6 cases(12.5%)were improved after simple diet intervention,16 cases(33.33%)were improved after treatment with montelukast,ketotifen,omeprazole,26 cases(54.17%)were improved after combined treatment with prednisone acetate.Followed up for 10 months to 3 years,8 cases(16.67%)relapsed after drug withdrawal and improved after retreatment.Conclusions The clinical symptoms and endoscopic manifestations of EG in children are diverse and lack of specificity,endoscopic mucosal histopathological examination is helpful for diagnosis.The EOS in peripheral blood of most children increased,diet intervention and glucocorticoid therapy are effective,but there is a possibility of recurrence,which need long-term maintenance treatment and follow-up.
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