Objective To evaluate the sedative effect of dexmedetomidine(Dex)combined with propofol or etomidate during cerebral aneurysm intervention and its effect on patient hemodynamics.Methods A total of 60 cerebral aneurysm patients were randomly divided into two groups:Group A(Dex+propofol,n=30)and Group B(Dex+etomidate,n=30).Mean arterial pressure(MAP)and heart rate(HR)were recorded at different time points in the two groups,and the sedation effect,choking degree,extubation time,waking up time,waking time and postoperative side effects were compared.Results T1 MAP,HR of(84.56±5.13)mmHg,(65.87±5.14)times/min and T2(83.29±5.47)mmHg,(65.87±5.14)times/min in group A were lower than those in group B T1(87.89±3.88)mmHg,(70.22±5.67)times/min and T2(86.71±3.75)mmHg,(69.97±5.87)times/min(t=2.836,2.825,3.113,3.391,all P＜0.001).There was no significant difference in the incidence of emergence agitation(10.00%vs 0.00%,P=0.757)and respiratory depression(3.33%vs 0.00%,P=0.313)between the two groups(P＞0.05).The incidence of nausea and vomiting in group A(3.33%)was lower than that in group B(20.00%)(χ2=4.043,P=0.044).Conclusions Dex combined with propofol and etomidate anesthesia can have a good and safe anesthesia effect in intracranial aneurysm intervention,and reduce the incidence of postoperative agitation and respiratory depression in patients.Hemodynamic stabilization during the tube phase is more effective,but less effective in reducing the risk of postoperative nausea and vomiting in patients.
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