Objective To investigate the correlation of YAP and p65 with clinical features in diffuse large B-cell lymphoma(DLBCL)and the significance for treatment and prognosis.Methods Tissues from 65 patients with DLBCL and 10 patients with reactive hyperplasia lymph node were collected for immunohistochemistry staining to analyze the differences between the two groups;statistical analysis and survival difference analysis of the correlation between various clinical features and YAP,p65 were performed.Results YAP and p65 staining scores were significantly different between the two groups(P＜0.05).YAP scores were positively correlated with efficacy subgroups,and negatively correlated with LDH levels before treatment,Ann-Arbor staging,and International Prognostic Index(IPI)scores before treatment(P＜0.05);p65 expression was negatively correlated with efficacy subgroups,and positively correlated with pretreatment LDH levels,Ann-Arbor subgroup,ECOG subgroup,extra-nodal invasion,IPI scores,and huge mass(P＜0.05).IPI and p65 score were independent prognostic risk factors for overall survival(OS)in DLBCL patients(P＜0.05).The mean value of OS was the lowest in patients in the YAP-/p65+group in the co-expression stratification.Conclusions Low expression of YAP or high expression of p65 suggests larger tumor load and poorer outcome and prognosis in patients for DLBCL.
维普
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