Objective To investigate the nursing and rehabilitation of chronic ankle instability with reinforcement fixation and repair of lateral ligament under arthroscopy.Methods The perioperative nursing measures and rehabilitation guidance of 31 patients with chronic ankle instability treated with lateral ligament reinforcement fixation under arthroscopy from January 2023 to August 2023 were analyzed retrospectively.Results None of the 31 patients was disassociated during follow-up.The American Orthopaedic Foot and Ankle Society(AOFAS)scores of the patients were significantly higher and higher at 3,6 and 12 months after surgery(all P<0.05).The Zung anxiety score and Zung depression score at 3 months after operation were significantly lower than those before operation(all P<0.05).None of the 31 patients had postoperative complications such as ankle instability recurrence,sural nerve injury,peroneal tendinitis and infection.Conclusions In arthroscopic reinforcement fixation of lateral ligament in the treatment of patients with chronic ankle instability,strengthening the perioperative nursing measures and rehabilitation guidance,plays an important role in restoring the stability and flexibility of the ankle,and is conducive to improving the quality of life and satisfaction of patients.