In order to explore the effect of drought stress on seed germination of Periploca forrestii Schltr,PEG-6000 solution with different concentration gradients was used to conduct stress experiments on Periploca forrestii seeds,and the relevant indexes of seed germination under different concentrations of PEG-6000 stress were ana-lyzed,the differences in seed germination characteristics under different concentrations of PEG-6000 stress were compared.The results showed that under medium and low concentration drought stress,the seeds of Periploca forrestii had a certain degree of stress resistance,while the high concentration of PEG-6000 inhibited seed ger-mination,its germination rate,germination potential,germination index and daily germination rate decreased with the increase of PEG-6000 concentration,and high drought stress had an inhibitory effect on seed germina-tion.With the increase of PEG-6000 concentration,the root length,stem length and seedling height of the seeds germinated by the seeds of Periploca forrestii were inhibited and gradually decreased.The malondialdehyde con-tent was proportional to the concentration of PEG-6000,and the overall trend was upward.The protein of seeds treated with low and medium concentrations of PEG-6000 gradually increased with the increase of concentration,while that of high concentration treatment decreased.The soluble saccharide content tended to be consistent with the concentration of PEG-6000.The comprehensive analysis showed that severe drought would inhibit the seed germination of Periploca forrestii,so the concentration of PEG-6000 should be moderately controlled in the future introduction and domestication process of Periploca forrestii.