促血管生成素-1与反复自然流产的相关性研究
Correlational study between angiopoietin-1 and recurrent spontaneous abortion
沈寅琛 1甘柏柳 1陆洪波 1王婧1
作者信息
- 1. 南宁市妇幼保健院优生遗传科,广西南宁 530011
- 折叠
摘要
目的 研究促血管生成素-1 (Ang-1)与反复自然流产(RSA)之间的相关性,探讨RSA的病因.方法 选择33例RSA患者和37例健康早孕人工流产妇女的绒毛膜组织,经免疫组化法检测其Ang-1的蛋白表达水平,并结合相应临床参数进行分析.结果 自然流产组绒毛膜组织中Ang-1的表达高于人工流产组,差异有统计学意义(P＜0.05)；两组Ang-1的表达均与年龄无关(P＞ 0.05)；自然流产组Ang-1的表达与胚胎孕周呈正相关(P＜0.05),而人工流产组Ang-1的表达与胚胎孕周无关(P＞0.05).结论 Ang-1的高表达可能是造成自然流产的原因之一.
Abstract
Objective To study the relationship between angiopoietin-1 and recurrent spontaneous abortion (RSA). Methods The expression levels of angiopoietin-1 in chorion of 33 patients with RSA (the study group) and 37 healthy early pregnant women undergoing artificial abortion (the control group) were detected by immunohisto-chemistry. The correlation between expression and clinicopathological parameters was also analyzed. Results The expression level of angiopoietin-1 in the study group were significantly higher than that in the control group (P<0.05). The expression of angiopoietin-1 in the two groups was not correlated with age (P>0.05). The expression of angiopoietin-1 was correlated with the fetal gestational age in the study group (P<0.05), but not in the control group (P>0.05). Conclusion The high expression of Angiopoietin-1 might be one of the reasons for spontaneous abortion.
关键词
反复自然流产/促血管生成素-1/绒毛膜Key words
Recurrent spontaneous abortion/Angiopoietin-1/Chorion引用本文复制引用
基金项目
南宁市科学研究与技术开发计划项目(201003049C-2)
出版年
2013
NETL
NSTL
维普
万方数据