Correlation between expression of GPER30,NPAS4,FKBP5 in peripheral blood and cognitive dysfunction in patients with small cerebral vascular disease
Objective To investigate the correlation between the expression of G protein-coupled estrogen re-ceptor 30(GPER30),neuronal PAS domain protein 4(NPAS4),FK506-binding protein 5(FKBP5)in peripheral blood and cognitive dysfunction(CD)in patients with small cerebral vascular disease(CSVD).Methods A prospective study was conducted on 227 patients with CSVD admitted to the Second Affiliated Hospital of Zhengzhou University from Jan-uary 2022 to December 2023.They were divided into a barrier group(n=66)and a non-barrier group(n=161)based on the presence or absence of CD.The general information and peripheral blood GPER30,NPAS4,FKBP5 mRNA expres-sion levels of the two groups of patients were compared.Logistic regression analysis was used to analyze the influencing factors of CSVD patients'CD.The peripheral blood GPER30,NPAS4,FKBP5 mRNA expression levels of patients with different degrees of CI were compared.Pearson correlation analysis was used to analyze the correlation between peripheral blood GPER30,NPAS4,FKBP5 mRNA expression and Montreal Cognitive Assessment(MoCA)scores.Results The age and disease duration of patients in the barrier group were(72.49±5.68)years and(2.69±0.78)years,respectively,which were significantly higher than(67.51±7.04)years and(2.31±0.62)years in the non-barrier group(P<0.05).The ex-pression level of GPER30 mRNA in peripheral blood of patients with obstacles was 1.02±0.17,which was significantly lower than 1.66±0.31 of patients without obstacles,and the expression levels of NPAS4 mRNA and FKBP5 mRNA were 2.79±0.60 and 3.88±1.12,respectively,which were significantly higher than 1.55±0.51 and 2.10±0.59 of patients without obstacles,with statistically significant differences(P<0.05).The results of logistic regression analysis showed that age,disease duration,GPER30 mRNA,NPAS4 mRNA,and FKBP5 mRNA were all independent factors affecting CD in pa-tients with CSVD(P<0.05).The expression of GPER30 mRNA in the peripheral blood of patients in the mild group was 1.27±0.25,which was significantly higher than 0.70±0.12 in the moderate and severe groups,and the expression levels of NPAS4 mRNA and FKBP5 mRNA were 2.31±0.58,3.19±1.07,which were significantly lower than 3.40±0.72,4.76±1.39 in the moderate and severe groups,with statistically significant differences(P<0.05).Pearson correlation analysis showed that the expression of GPER30 mRNA in peripheral blood was positively correlated with the MoCA score in CS-VD patients(r=0.704,P<0.05),while NPAS4 mRNA and FKBP5 mRNA were negatively correlated with MoCA score(r=-0.572,-0.542,P<0.05).Conclusion GPER30,NPAS4,and FKBP5 in peripheral blood are independent correlation factors of CD in CSVD patients,and the expression level of each indicator is correlated with the severity of CD to some extent,which can provide reference for clinical judgment and evaluation of the severity of CD and can guide the fol-low-up clinical work.
Small cerebral vascular diseaseG protein-coupled estrogen receptor 30(GPER30)Neuronal PAS domain protein 4(NPAS4)FK506 binding protein 5(FKBP5)Cognitive dysfunctionCorrelation
万方数据
维普
