Relationship between serum PDGF,OPN levels and prognosis of TACE treatment for primary liver cancer
Objective To investigate the relationship between serum levels of platelet-derived growth factor(PDGF)and osteopontin(OPN)and the prognosis of patients with primary liver cancer(PLC)treated with transcatheter arterial chemoembolization(TACE).Methods A prospective study was conducted on 110 patients with PLC admitted to Nanyang Central Hospital from October 2021 to May 2023.All patients'serum PDGF and OPN levels were measured upon admission.All patients underwent TACE treatment and were followed up for one year after discharge.According to the prognosis,they were divided into poor prognosis and good prognosis groups.Baseline data and serum PDGF and OPN levels were compared between two groups of patients.Multivariate logistic analysis was used to investigate the in-fluencing factors of TACE treatment prognosis in PLC patients after TACE treatment.Receiver operating characteristic(ROC)curves were constructed to analyze the predictive value of PDGF and OPN for the prognosis of TACE treatment in PLC patients,and decision curve analysis(DCA)was performed to evaluate the clinical benefits of PDGF and OPN in predicting the prognosis of TACE treatment in PLC patients.Results A total of 108 PLC patients completed a one-year follow-up,with 29 classified into the poor prognosis group and 79 patients into the good prognosis group.The maximum tumor diameter,alpha-fetoprotein(AFP),PDGF,and OPN in the poor prognosis group were(4.91±0.86)mm,(494.74±100.09)μg/L,(429.28±92.30)pg/mL,and(115.82±20.45)ng/mL,respectively,significantly higher than corresponding(4.20±0.82)mm,(411.15±88.10)μg/L,(350.46±74.93)pg/mL,and(97.37±16.53)ng/mL in the good prognosis group,with statistically significant differences(P<0.05).Multivariate logistic regression analysis indicated that tumor maxi-mum diameter,AFP,PDGF,and OPN were all risk factors for poor prognosis in PLC patients after TACE treatment(P<0.05).The ROC curve results showed that the areas under the curve(AUC)for predicting poor prognosis in PLC patients after TACE treatment using serum PDGF,OPN alone,and their combination were 0.739,0.768,and 0.844,respectively,with the AUC of combined detection significantly higher than that of each indicator alone(P<0.05).Decision curve analysis(DCA)revealed that within the threshold ranges of 0.10 to 0.57 and 0.81 to 0.97,the net benefit rate of com-bined of detection PDGF and OPN was significantly superior to that of single indicator.Moreover,within the high-risk threshold ranges of 0.10 to 0.70 and 0.75 to 0.97,the combined detection yielded a net return rate>0,with a maximum net return rate of 0.269.Conclusion Serum PDGF and OPN levels are related to the prognosis of PLC patients after TACE treatment and have a certain value in predicting prognosis.The combination of the two indicators can improve predictive efficiency.
万方数据
维普
