Correlation of AGEs,Apelin,Omentin-1 with the time of blood glucose within the target range in patients with T2DM and their ability to warn of concurrent microvascular complications
Objective To study the correlation of serum advanced glycation end products(AGEs),Apelin,Omentin-1 with time in range(TIR,the time of blood glucose within the target range)in patients with type 2 diabetes mellitus(T2DM),as well as their ability to warn of concurrent microvascular complications.Methods A prospective study was conducted to select 120 patients with T2DM admitted to the First Affiliated Hospital of Xinxiang Medical University from May 2021 to June 2024.They were divided into a concurrent group(n=52)and a non-concurrent group(n=68)based on whether they had concurrent microvascular disease.The baseline data and serum levels of AGEs,Ape-lin,and Omentin-1 were compared between the two groups of patients.Pearson correlation analysis was used to analyze the correlation between serum AGEs,Apelin,Omentin-1 and TIR.Multivariate logistic regression analysis was used to analyze the effect of serum AGEs,Apelin,and Omentin-1 on T2DM complicated with microvascular disease.The receiv-er operating characteristic(ROC)curve and area under the curve(AUC)were used to evaluate the predictive ability of serum AGEs,Apelin,and Omentin-1 for the development of microvascular disease.Results The duration of T2DM in the concurrent group was(9.01±1.35)years,which was significantly longer than(8.53±1.24)years in the non-concurrent group;the glycosylated hemoglobin was(8.92±0.50)%,which was significantly higher than(7.15±0.78)%in the non-concurrent group;the TIR was(46.73±10.22)%,which was significantly lower than(68.82±7.61)%in the non-con-current group;the differences were statistically significant(P<0.05).The serum AGEs and Apelin in the concurrent group were significantly higher than those in the non-concurrent group,while the serum Omentin-1 in the concurrent group was significantly lower than that in the non-concurrent group,with statistically significant differences(P<0.05):AGEs,(20.35±6.74)μ g/mL vs(14.10±4.69)μ g/mL;Apelin,(6.20±2.03)ng/mL vs(4.19±1.27)ng/mL;Omentin-1,(50.87±14.56)ng/mL vs(72.56±22.97)ng/mL.Pearson correlation analysis showed that serum AGEs and Apelin were negatively correlated with TIR(r=-0.759,-0.762,P<0.05),while Omentin-1 was positively correlated with TIR(r=0.733,P<0.05).The results of the multivariate logistic regression analysis indicated that serum levels of AGEs,Apelin,and Omentin-1 are independently associated with the development of microvascular complications in patients with T2DM(P<0.05).The ROC curve results showed that the areas under the curve for serum AGEs,Apelin,Omentin-1,and their combination in predicting the development of microvascular complications in patients were 0.787,0.798,0.796,and 0.935,respectively,with the combination having greater predictive value.Conclusion The abnormal expression of serum AGEs,Apelin,and Omentin-1 levels in T2DM patients is associated with TIR and concurrent microvascular dis-ease.The combination of the three is helpful to improve the predictive efficacy of T2DM patients with concurrent micro-vascular disease.
Type 2 diabetes mellitusAdvanced glycation end productsApelin peptideOmentin-1Time of blood glucose within the target rangeMicrovascular disease
万方数据
维普
