Value of IL-8 and IL-10/TNF-α ratio interaction in evaluating the condition of patients with bronchiectasis complicated by pulmonary infection
Objective To explore the value of the interaction between peripheral blood interleukin-8(IL-8)and interleukin-10(IL-10)/tumor necrosis factor alpha(TNF-α)ratio in evaluating the condition of patients with bron-chiectasis complicated by infection,in order to provide reference for clinical diagnosis and treatment.Methods A total of 85 patients with bronchiectasis complicated by pulmonary infection treated at Xinyang Central Hospital from January 2021 to August 2023 were selected as the infection group,and 85 patients with simple bronchiectasis were selected as the non-infection group.The peripheral blood IL-8 and IL-10/TNF-α ratio of the two groups of patients were com-pared.Patients in the infection group were divided into mild group(20 cases),moderate group(47 cases)and severe group(18 cases)according to the bronchiectasis severity index(BSI),and divided into mild infection group(26 cases),moderate infection group(44 cases),and severe infection group(15 cases)according to the pulmonary infection score(CPIS).The peripheral blood IL-8,IL-10/TNF-α ratio and respiratory function(forced expiratory volume in one second(FEV1),FEV1 to forced vital capacity[FEV1/FVC])were compared among patients with different degrees of bronchiecta-sis severity and infection severity in the infection group.The correlation between the levels of IL-8 and IL-10/TNF-α in peripheral blood and respiratory function,infection severity,and degree of dilation in the infection group was analyzed using Pearson and Spearman methods.The interaction between the ratio of IL-8,IL-10/TNF-α in peripheral blood and infection in patients with bronchiectasis was analyzed using the interaction coefficient γ.The diagnostic value of periph-eral blood IL-8 and IL-10/TNF-α ratio for bronchiectasis with infection was analyzed using receiver operating charac-teristic(ROC)curve.Results The levels of IL-8,IL-10,TNF-α,and the ratio of IL-10/TNF-α in the peripheral blood of patients in the infection group were significantly higher than those in the non-infection group,and the differences were statistically significant(P<0.05).The levels of IL-8,IL-10,TNF-α,and the ratio of IL-10/TNF-α in peripheral blood gradually decreased with the aggravation of the degree of dilation,while they gradually increased with the aggrava-tion of the degree of infection.FEV1 and FEV1/FVC gradually increased with the aggravation of the degree of dilation,while they gradually decreased with the aggravation of the degree of infection,with statistically significant differences(P<0.05).According to Pearson's analysis,the ratio of IL-8 and IL-10/TNF-α in peripheral blood of patients in the in-fection group was negatively correlated with FEV1(r=-0.591,-0.570)and FEV1/FVC(r=-0.580,-0.538),P<0.05.Ac-cording to Spearman's analysis,the ratio of IL-8 and IL-10/TNF-α in peripheral blood of patients in the infection group was positively correlated with the degree of infection(r=0.538,0.570)and the degree of dilation(r=0.603,0.619),P<0.05.The interaction analysis showed that high levels of IL-8 and a high IL-10/TNF-α ratio had a positive interaction in bronchiectasis with infection(RR=8.038,95%CI:3.403 to 18.988),and this was a secondary multiplicative model.ROC analysis results showed that the area under the curve(AUC)of the combined detection of IL-8 and IL-10/TNF-α ratio for diagnosis of bronchiectasis with infection was 0.907(95%CI:0.853 to 0.946),which was superior to that of each in-dicateor alone(P<0.05).Conclusion The expression of IL-8 and IL-10/TNF-α ratio in peripheral blood of patients with bronchiectasis complicated by infection is up-regulated,and there is a positive interaction.Combined detection has certain diagnostic value for bronchiectasis complicated by infection,and can be used as an auxiliary indicator for clinical diagnosis and disease assessment,as well as for guiding clinical decision-making.
万方数据
维普
