Analysis on the results of therapeutic drug monitoring to 12 275 times of five second-generation antipsychotics
Objective To analyze concentration monitoring data of 5 second-generation antipsychotic drugs,and to provide reference for rational clinical use of drugs.Methods The concentration data of 5 second-generation anti-psychotic drugs(including aripiprazole,olanzapine,quetiapine,clozapine,and risperidone)and its metabolite paliperidone in the clinical laboratory of the Second People's Hospital of Huizhou from January to December 2022 were collected,and then the subsequent data were statistically analyzed.Results A total of 12 275 monitoring times were performed in 4 112 patients for the 5 drugs.Among all the tested drugs,olanzapine had the highest monitored times at 5 319(43.32%),and quetiapine had the lowest monitored times at 1 397 times(11.38%).The proportion of monitoring times at 1 was higher in outpatients than inpatients,and the proportion of monitoring more than 3 times was higher in inpatient than out-patient,with statistically significant differences(P<0.01).The blood concentrations of aripiprazole,clozapine,and risper-idone+paliperidone in patients≥60 years old were significantly higher than those in patients<60 years old,and the dif-ferences were statistically significant(P<0.05).There was no statistically significant difference in olanzapine and que-tiapine between patients aged≥60 years and those aged<60 years(P>0.05).Among the five drugs,quetiapine,risperi-done+paliperidone had the highest proportion in the therapeutic reference concentration range,about 60%,and clozapine had the lowest proportion in the therapeutic reference concentration range,at 25.20%.The plasma concentrations of olan-zapine,quetiapine,risperidone+paliperidone had good consistency with the consensus recommended reference range,while clozapine was significantly lower than the consensus recommended reference range.Conclusion In the process of clinical antipsychotic drug treatment,clinicians should pay attention to the monitoring of therapeutic drugs in outpa-tients and inpatients,so as to provide guarantee for safe and effective individualized medication.
万方数据
维普
