Research progress on the mechanism of acute renal injury induced by wasp stings injury mediated by Bax/Bcl-2
Severe wasp stings often lead to acute kidney injury(AKI),and its occurrence is closely associated with disease severity,intensive care unit(ICU)stay,and poor prognosis.The mechanism of this pathological process is generally believed to be related to the toxic effects of wasp venom and the inflammatory and immune responses it induc-es.Wasp venom can directly affect renal tubules,leading to apoptosis of renal tubular epithelial cells,while also exacer-bating renal dysfunction by mediating immune-inflammatory responses.However,the specific molecular mechanisms are not yet fully elucidated.The balance between Bax and Bcl-2 plays a key role in maintaining cellular homeostasis and function.Previous studies have shown that the overexpression of Bax/Bcl-2 can induce endothelial cell apoptosis and in-flammation through the activation of the TNF-α pathway,contributing to the development of AKI.However,research on the role of Bax/Bcl-2 balance in wasp venom-induced AKI is relatively scarce.This paper will review the relevant mech-anisms of wasp stings,focusing on the apoptotic mechanisms mediated by Bax/Bcl-2,and discuss the potential applica-tion prospects of Bax/Bcl-2 in the treatment of AKI based on the latest research.
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