Cardiovascular disease is the leading cause of morbidity and mortality among patients with diabetes.Epidemiological and genetic studies have consistently shown that individuals with type 2 diabetes have a significantly higher risk of cardiovascular disease,primarily due to lipid metabolism disorders.Current lipid management guidelines predominantly recommend targeting low-density lipoprotein cholesterol(LDL-C)as the primary intervention.However,even with statin therapy,many type 2 diabetes patients continue to experience considerable residual cardiovascular risk.Recent research on residual cholesterol has provided insights that may help explain this phenomenon.This review ex-plores the role of residual cholesterol in patients with type 2 diabetes and coronary heart disease,aiming to enhance the prediction of residual risk and offer improved prevention and treatment strategies for these patients.
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