Systematic Evaluation of Jinshuibao in Treatment of Early Diabetic Nephropathy
Objective To systematically evaluate the effectiveness and safety of Jinshuibao in the treatment of early diabetic nephropathy.Method Comprehensive searches were conducted in foreign language databases such as PubMed,Cochrane Library,Web of Science and Em-base,and Chinese databases such as CNKI,Wanfang and CQVIP,with a timeframe from the construction of the database to July,2023.The methodological quality of the subjects was as-sessed according to the assessment criteria of the Cochrane Assessment Handbook 5.3.3.Rev-Man 5.4 software was used to analyze relevant data.Results This study included 20 articles in the literature,including a total of 1,514 patients(758 in the observation group and 756 in the control group).Meta analysis results show that the total efficiency of the observation group is higher than that of the control group[RR =2.53,95%CI(1.77,3.62),P<0.00001];UAER in the ob-servation group is higher than that of the control group[MD =-34.67,95%CI(-41.76,27.58),P<0.00001];the blood SCr in the observation group is lower than that of the control group[MD=-13.01,95%CI(-15.61,-10.41),P<0.00001];the BUN level in the observation group is lower than that of the control group[MD=-1.38,95%CI(-2.06,-0.69),P<0.00001]:the HbA1C level of the observation group is lower than that of the control group[MD=-0.63,95%CI(-1.14,-0.13),P<0.00001].The results of l7 randomized controlled trials showed a significant reduction in urinary micro-protein excretion rate(UAER)before and after treatment for diabetic nephropathy(P<0.0001).17 randomized controlled trials showed a significant reduction in urinary micro-protein excretion rate(UAER)before and after treatment for diabetic nephropathy(P<0.0001).Con-clusion The existing clinical evidence shows that Jinshuibao combined with western medicine in the treatment of early diabetic nephropathy is more effective than that of simple western medi-cine,which is worthy of clinical promotion and application,but more multi-center large sample randomized controlled trials(RCTs)studies are needed for verification.
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