Meta Analysis of Efficacy of Huangjing Zanyu Capsule in the Treatment of Male Infertility
Objective To systematically evaluate the effectiveness of Huangjing Zanyu Capsule in the treatment of male infertility and provide evidence-based evidence for its clinical application.Method Computer searches were conducted on six databases,including CNKI,Wanfang,VIP,CBM,PubMed,and Web of Science.The search period was from the establishment of each da-tabase until December 31,2021,and the search language was limited to both Chinese and Eng-lish.Randomized controlled trials of Huangjing Zanyu capsule for the treatment of male infertility were collected,the quality of the literature was evaluated using Co-chrane Handbook 5.1.0,and Meta-analysis of the included clinical studies was performed using RevMan 5.3 software.Result 277 relevant literature were retrieved,and 8 studies were ultimately included with a total sample size of 910.The study baseline was comparable.The meta-analysis results showed that the ef-fective rate of Huangjingzanyu Capsule in treating male infertility[RR=1.48,95%CI(1.32,1.65),P<0.00001],spouse pregnancy rate[RR=3.93,95%CI(2.13,7.25),P<0.0001],sperm concentra-tion[MD=9.71,95%CI(3.00,16.42),P=0.005],sperm motility[MD=9.41,95%CI(1.36,17.46),P =0.02],a-grade sperm[MD=4.99,95%CI(3.56,6.41),P<0.00001],normal morphology of sperm[MD=1.98,95%CI(0.33,3.63),P=0.02]were higher than those of the control group.There was no statistically significant difference in the treatment of male infertility with Huangjingzanyu cap-sules for grade a+b sperm[MD=9.78,95%CI(-3.53,23.09),P=0.15]compared with the control group.Conclusion Huangjing Zanyu Capsule can improve the treatment effectiveness,spouse pregnancy rate,sperm concentration,sperm motility,A-grade sperm ratio,and normal sperm morphology rate in the treatment of male infertility.This preliminarily confirms that Huangjing Zanyu Capsule has a significant therapeutic effect on male infertility.
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