The Contents of Neoaconitine,Aconitine and Hypoaconitine Before and after the Combination of Miao Medicine Radix Aconiti and Sanguisorba Officinalis L
Objective To study the changes of the contents of Neoaconitine,Aconitine and Hy-poaconitine in Radix Aconiti(RA)-Sanguisorba officinalis L(SOL)lyophilized powder(1 ∶ 2)wine solution and aqueous solution.Method The contents of Neoaconitine,Aconitine and Hy-poaconitine before and after RA-SOL were determined by high performance liquid chromatog-raphy(HPLC).Results The content of three diester alkaloids in RA-SOL lyophilized powder(1∶ 2)wine solution decreased by 97.3%compared with that of RA freeze-dried powder solu-tion.The content of three diester alkaloids in RA-SOL lyophilized powder(1 ∶ 2)aqueous solu-tion decreased by 96.7%compared with the aqueous solution of RA freeze-dried powder.Con-clusion The RA-SOL of lyophilized powder(1 ∶ 2)can reduce the content of Neoaconitine,A-conitine and Hypoaconitine in RA,play a role in attenuation,and provide guidance for revealing the mechanism of drug reduction and compatibility in the preparation of RA.
Radix AconitiSanguisorba officinalis LCompatibility to reduce toxicityNeo-a-conitineAconitineTimes of aconitineAlkaloids
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