Prognostic Value of Systemic Inflammatory Indicators and Ultrasound Features in Central Lymph Node Metastasis of Unilateral Thyroid Micropapillary Carcinoma of cN0
Objective To investigate the preoperative systemic inflammatory response index(SI-RI),systemic immunoinflammatory index(SII),neutrophil count/lymphocyte count(NLR),platelet count/lymphocyte count(PLR),lymphocyte count/monocyte count(LMR)and ultra-sonic features of cN0 unilateral papillary thyroid carcinoma(PTMC)in central lymph Predictive value of junction transfer.Methods The clinical data of 208 patients with cN0 unilateral PTMC ad-mitted to the First Affiliated Hospital of Anhui University of Science and Technology from July 2020 to December 2021 were retrospectively analyzed.The patients were divided into a metasta-sis group(n=64)and a non-metastasis group(n=144)according to whether there was central lymph node metastasis in postoperative pathology.Preoperative SIRI,SII,NLR,PLR,LMR and ultrasound features were compared between the two groups.Statistical analysis was performed using SPSS 19.0 software.T test was used to compare the normal distribution between the measurement data groups.Mann-Whitney U test was used to compare the non-normal distri-bution measurement data groups.Enumeration data were represented by example,and compar-ison between groups was performed by chi-square.Multivariate factor analysis was performed by binary Logistic regression analysis.Receiver Operating characteristic(ROC)curves were de-veloped to predict risk factors for central lymph node metastasis,and area under the curve(AUC)was calculated.Results In 208 PTMC patients with cN0,the rate of central lymph node metastasis was 30.77%(64/208).There was no significant difference in unclear boundaries,mi-crocalcification,multi-focus,SIRI,SII,NLR,PLR and LMR between the metastatic group and the non-metastatic group(P>0.05).In the metastatic group,the proportion of male patients,tumor diameter,proximity to envelope and enriched blood flow signal,the difference between the two groups was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that tumor diameter,proximity to envelope and enriched blood flow signal were inde-pendent risk factors for central lymph node metastasis(P<0.05).The area under ROC curve(AUC)of tumor diameter,enriched blood flow signal and tumor diameter combined with en-riched blood flow signal prediction of cN0 unilateral PTMC lymph node metastasis were 0.663(0.582-0.744),0.668(0.591-0.746)and 0.706(0.634-0.778),respectively(P<0.001),and the cutoff value of tumor diameter prediction was 0.55 cm.Conclusion The central lymph node me-tastasis rate of cN0 unilateral PTMC is high.Lymph node metastasis should be warned in pa-tients with tumor diameter>0.55cm and enriched blood flow signal,the combination of the two can improve predictive power.
万方数据
维普
