Study on the Relationship between Prognostic Nutrition Index and Cognitive Impairment after Acute Ischemic Stroke
Objective To investigate the relationship between prognostic nutritional index(PNI)and cognitive function in patients with acute ischemic stroke.Methods Study participants were recruited from the neurological treatment center of our hospital.PNI index was calculated by al-bumin and lymphocyte,and the best cutoff value of PNI in diagnosing post-stroke cognitive im-pairment was determined according to diagnostic tests.The subjects were divided into low PNI group(PNI≤52.2,n=152)and high PNI group(PNI>52.2,n=73).The Montreal Cognitive Scale(MOCA)was assessed 2 weeks after stroke onset.When MOCA≤22,patients with post-stroke cognitive impairment were considered.Binary logistic regression was used to evaluate the relationship between PNI index and the risk of cognitive impairment after stroke.Receiver operating curve(ROC)was used to evaluate the value of PNI in predicting cognitive impair-ment in patients with acute ischemic stroke.Results The study population included 225 patients with a mean age of(60.74±0.81)years.At 2 weeks,the proportion of patients with MOCA≤22 was 48.9%.PNI≤52.2 was the influential factor for the occurrence of post-stroke cognitive im-pairment(OR=5.3595%CI:1.74～16.43,P=0.003),and with the decrease of PNI index,the risk of post-stroke cognitive impairment gradually increased.PNI index was positively correlated with MOCA score at 2 weeks in patients with ischemic stroke(r=0.367,P<0.001),and PNI in-dex predicted an area under the PSCI curve of 0.7(95%CI:0.63-0.77).Conclusion PNI index is a simple and effective score,which has certain predictive value for the risk of PSCI in patients with ischemic stroke,and is helpful for early diagnosis and clinical intervention.
post stroke cognitive impairmentischemic strokeprognostic nutritional indexalbuminlymphocyte
万方数据
维普
