Blood Flow Changes in the Uterus and Ovaries Before and After Metformin Treatment for Polycystic Ovary Syndrome Assessed with Colour Doppler
Objective To investigate the ovarian color Doppler parameters and serum hormone indexes in polycystic ovary disease(PCOD)and evaluate the changes of color Doppler mor-phology and parameters of ovaries in patients with polycystic ovary syndrome(PCOS)before and after metformin treatment.Methods A total of 120 patients with PCOD were enrolled from January 2019 to December 2022,of which 96 were diagnosed with PCOS according to Rotter-dam criteria,and 24 were diagnosed with PCOM.The changes in serum follicle-stimulating hor-mone(FSH),luteinizing hormone(LH),bilateral ovarian volume,number of follicles,interstitial echo,ovarian artery RI,uterine artery RI,and metformin were recorded after three months of treatment.Results There was a significant correlation between LH and LH/FSH ratios and ovari-an stromal RI in PCOD patients(r=0.403,r=0.654,P<0.01),and LH was negatively correlated with ovarian artery RI values.The RI value of ovarian artery in PCOS patients was significantly lower than that of normal ovaries,and the RI of uterine arteries was increased.The mean ovari-an volume of the PCOS group was considerably higher than that of the PCOM group(P<0.05).The mean RI of the ovarian artery in the PCOS group was significantly lower than that of the PCOM group(P<0.01).There was no significant difference in the RI value of the uterine artery between the two groups(P>0.05).The LH and LH/FSH ratio in the PCOS group was signifi-cantly higher than that in the PCOM group(P<0.01).After three months of metformin treat-ment,the ovarian volume,LH,uterine artery RI,and LH/FSH ratio in the PCOS group were low-er than before treatment,and the ovarian artery RI and FSH were higher than before treatment.Conclusion Color Doppler ultrasound is a good tool for diagnosing PCOD.Doppler helps evaluate the hemodynamic changes of small blood vessels in utero-ovarian circulation and evaluate clini-cal treatment efficacy.
PCOScolor dopplermetforminuterine artery RIovarian artery RI
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