Effects of L-carnitine on Blood Lipid Metabolism and Antioxidation in Hyperlipidemia Rats
50 healthy SD rats were randomly divided into 5 groups and fed with control diet, high-cholesterol diet and high-cholesterol diet adding L-carniline (LC)at different dose [0.25,0.50 and 1.00 g/(kg-d)] by orally administration to study the effects of LC on the blood lipid metabolism in hyperlipidemia rats and its antioxidation. The content of total cholesterol (TC), triglyceride(TG), high density lipoprotein(HDL-C) and low density lipoprotein(LDL-C) in serum, the activity of superoxide dismutase (SOD) and the content of malondiadehyde (MDA) in serum and liver of each group were detected after 28 days. The results showed that compared with hyperlipid model group, the content of TC, TG and LDL-C in the serum of LC treated group was significantly decreased; the HDL—C level was increased; the SOD activities in serum and liver were higher and the MDA contents were decreased (P<0.05). It was indicated that LC might play an important role in lowering the high blood lipid and improving the vivo antioxidant capacity in hyperlipidemia rats.
NETL
NSTL
万方数据
维普
