Extraction process of total flavonoids from stigma maydis and Gynostemma pentaphyllum and preparation of the antihypertensive tablets
Taking stigma maydis and Gynostemma pentaphyllum(1∶1)as the extraction raw material and the total flavonoids content as the investigation index,the effect of compound total flavonoids content was investigated by single factors including extraction sol-vent,ethanol volume fraction,extraction temperature,extraction time,material-liquid ratio and extraction times.Then,the extrac-tion process of total flavonoids was optimized by the orthogonal test.Finally,the optimized total flavonoids were refined by D101 mac-roporous adsorption resin and prepared into antihypertensive tablets.The results showed that the best extraction process of compound total flavonoids was 50%ethanol volume fraction,the material-liquid ratio was 1∶10,and the extraction time was 3.5 h at 50℃.The quality of the prepared tablets(weight difference±5.1%,fragmentability 0.83%,disintegration time 2.41 min)was in line with the rel-evant provisions of the Pharmacopoeia of the People's Republic of China(2020 edition),and the antihypertensive tablets could re-duce the blood pressure of SHR rats.
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