Optimization of forming process of Zhuang medicine Luoqianyu cataplasm based on AHP-CRITIC method combined with star design
Taking the initial viscosity,holding viscosity and comprehensive sensory evaluation as indexes,the weight of each index was determined by the AHP-CRITIC mixed weighting method,and the comprehensive score was calculated.The star design-response surface method was used to optimize the best forming process of Zhuang medicine Luoqianyu cataplasm.The results showed that the best blank matrix formulation of Zhuang medicine Luoqianyu cataplasm was NP-700 of 1.6 g,silica gel powder of 1.0 g,dihydroxyalu-minum aminoacetate of 0.8 g,glycerol of 12.0 g,carbomer 940 of 0.5 g,CMC-Na of 0.5 g,EDTA-2Na of 26 mg,and deionized wa-ter of 10 mL.The preparation method was as follows:NP-700,silica gel powder and dihydroxyaluminum aminoacetate were swelled in glycerol as phase A,EDTA-2Na was dissolved in deionized water,carbomer 940 and CMC-Na were swelled as phase B,phase A was added into phase B to stir evenly,and the resulting blank matrix was mixed evenly with the prescribed cream.The optimized prepara-tion process was stable and feasible,and the actual production was operable,which could be used for the preparation of Zhuang medi-cine Luoqianyu cataplasm.
Zhuang medicine Luoqianyu cataplasmAHP-CRITICstar designforming process
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