藻蓝蛋白对小鼠皮肤损伤的治疗效果
The therapeutic effect of phycocyanin on skin damage in mice
邵丽林 1解佑银 1张雷芳1
作者信息
- 1. 浙江海洋大学食品与药学院/浙江省海洋生物医用制品工程技术研究中心,浙江 舟山 316022
- 折叠
摘要
为探讨藻蓝蛋白(CPC)对小鼠皮肤损伤的治疗效果,将ICR小鼠分为正常对照组(Con)、模型组(Mod)、空白敷料组(BD)、藻蓝蛋白敷料组(CPC TDD)和藻蓝蛋白敷料+藻蓝蛋白腹腔注射组(CPC+ip.)5个处理组进行小鼠烫伤试验.结果表明,CPC TDD组和CPC+ip.组伤口愈合时间最短,可以降低血清中丙二醛(MDA)含量,提高超氧化物歧化酶(SOD)含量,降低血清中炎症因子TNF-α和IL-6的水平.藻蓝蛋白通过增强机体抗氧化能力,降低炎症因子水平,从而对皮肤损伤的愈合起到促进作用.
Abstract
To investigate the therapeutic effect of C-phycocyanin(CPC)on skin injuries in mice,ICR mice were divided into five groups:normal control group(Con),model group(Mod),blank dressing group(BD),CPC-treated dressing group(CPC TDD),and CPC-treated dressing plus intraperitoneal injection of CPC group(CPC+ip.)for conducting mouse scalding experiments.The re-sults showed that the wound healing time was the shortest in the CPC TDD and CPC+ip.groups,which could reduce the content of malondialdehyde(MDA)in serum,increase the content of superoxide dismutase(SOD),and decrease levels of inflammatory factors TNF-α and IL-6 in serum.Phycocyanin could promote skin injury healing by enhancing antioxidant capacity and reducing levels of in-flammatory factors.
关键词
藻蓝蛋白/小鼠/皮肤损伤/伤口愈合/烫伤/海水浸泡Key words
C-phycocyanin/mice/skin injury/wound healing/scalding/seawater immersion引用本文复制引用
基金项目
浙江省高等学校和科研院所基本科研业务费专项(2019J00013)
国家自然科学基金(81903693)
舟山市科技计划(2020C21018)
国家级大学生创新创业训练计划(201910340019)
出版年
2024
NETL
NSTL
万方数据