首页|基于熵权TOPSIS法优选复方茯苓山药颗粒成型工艺及其薄层鉴别

基于熵权TOPSIS法优选复方茯苓山药颗粒成型工艺及其薄层鉴别

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以清膏相对密度、清膏与稀释剂配比、可溶性淀粉与糊精配比为考察因素，采用L9(34)正交试验法筛选复方茯苓山药颗粒最佳成型工艺。并选择成型率、水分、休止角为指标，结合熵权TOPSIS法综合评价其最佳成型工艺。采用TLC法鉴别茯苓、山药、薏苡仁和山楂。结果表明，TOPSIS模型排名结果与正交试验优化得到的最优结果基本相符，说明建立的模型是成功的。TLC图斑点清晰，分离度好，阴性无干扰。熵权TOPSIS模型的各评价指标主次分明，对于优选复方茯苓山药颗粒成型工艺是一种实用、快捷、有效的多目标决策分析的综合评价方法。薄层鉴别方法可行、准确有效，可用于复方茯苓山药颗粒的质量控制，为此方的接续研究给予参照。
Preparation process optimization of Compound Fuling Shanyao Granules based on entropy weight TOPSIS method and its TLC identification
Taking the relative density of clear paste,the ratio of clear paste and thinner,and the ratio of soluble starch and dextrin as the investigation factors,the L9(34)orthogonal test method was used to screen the best molding process Compound Fuling Shanyao Granules.The molding rate,moisture and resting angle were selected as indexes,and the best molding process was evaluated with the entropy weight TOPSIS method.The TLC method was used to identify Poria cocos,Chinese yam,Semen Coicis and Crataegus pinnati-fida.The results showed that the TOPSIS model ranking results basically agreed with the optimal results obtained by the orthogonal test,indicating that the established model was successful.The TLC spots were clear,with good separation and no negative interfer-ence.The evaluation index of the entropy weight TOPSIS model was clearly defined,which was a practical,rapid and effective compre-hensive evaluation method for the multi-objective decision analysis of selecting the best molding process of Compound Fuling Shanyao Granules.The TLC identification method was feasible,accurate and effective,which could be used for the quality control of Com-pound Fuling Shanyao Granules.This experiment could provide a basis for the follow-up study of this prescription.

Compound Fuling Shanyao Granulesentropy weight TOPSISorthogonal testthin-layer chromatography(TLC)

董琳琳、刘相岑、钟以凝、梁燕芳、陈秋华、陈卫卫

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广西中医药大学药学院/广西高校中药制剂共性技术研发重点实验室/广西壮瑶药重点实验室,南宁 530022

复方茯苓山药颗粒 熵权TOPSIS 正交试验 薄层色谱法(TLC)

广西壮瑶药重点实验室自主研发课题广西壮瑶药重点实验室自主研发课题广西壮瑶药重点实验室壮瑶药协同创新中心广西壮族自治区民族药资源与应用工程研究中心广西中医药重点学科壮药学广西重点研发计划项目广西科技基地和人才专项

GXZYZZ2022-18GXZYZZ2020A-08桂科基字[2014]32号桂教科研[2013]20号桂发改高技函[2020]2605号GZXK-Z-20-64桂科AB21196016桂科AD21238031

2024

10.14088/j.cnki.issn0439-8114.2024.10.026

湖北农业科学
湖北省农业科学院　华中农业大学　长江大学　黄冈师范学院

湖北农业科学

CSTPCD
影响因子：0.442
ISSN：0439-8114
年,卷(期)：2024.63(10)