吡那地尔对慢性心力衰竭大鼠心功能影响的研究
Effect of pinacidil on the cardiac function in rats with chronic heart failure
马力 1杨进刚 2史旭波 2李田昌 2胡大一 3刘杰 4初楠5
作者信息
- 1. 100050 北京市,首都医科大学附属北京天坛医院心内科
- 2. 首都医科大学附属北京同仁医院心脏中心
- 3. 北京大学人民医院心内科
- 4. 首都医科大学附属康复医院内科
- 5. 大连大学附属中山医院循环内科
- 折叠
摘要
目的 评价ATP的感性钾通道(KATP)开放剂吡那地尔对大鼠慢性压力超负荷性左心室肥厚/心力衰竭模型动物心功能的影响.方法 将成年Wistar大鼠60只随机分为3组:手术药物组(A组)、手术对照组(B组)和假手术对照组(C组),A组大鼠从术后4周开始应用吡那地尔,比较术后第12周和16周B型钠尿肽(BNP)及血流动力学监测指标的变化.结果 腹主动脉缩窄术后12周,B组左心室收缩末压(LVSP)显著升高(P＜0.05),A组LVSP值明显低于B组(P＜0.01),术后16周时低于C组(P＜0.05).A、B组+dP/dt明显低于C组(P＜0.01),术后16周A组+dP/dt略有回升.A、B组- dP/dt值在术后均明显低于C组(P＜0.01),A组略高于B组(P＞0.05).B组BNP在腹主动脉缩窄术后均明显高于C组(P＜0.01),A组BNP水平在术后12周明显高于C组(P＜0.05),第16周与C组相当(P＞0.05),均低于同期的B组(P＜0.05或＜0.01).结论 吡那地尔可显著改善慢性压力超负荷性心力衰竭模型大鼠的心功能.
Abstract
Objective To investigate the effects of pinacidil on the cardiac function in different time points in rat models with chronic heart failure. Methods Sixty Wistar rats were randomly divided into three groups: group A ( aortic banding group plus pinacidil) , group B ( aortic banding group) and group C ( sham-operation group). Pinacidil was used at 4 weeks after the operation, and BNP concentration and hymodanamic parameters were detected for the three groups at 12 week and 16 week after the operation. Results The LVSP in group B was increased at 12 weeks after operation ( P <0.01) ,and LVSP in group A was significantly lower than that of group B( P < 0. 01) , which was lower than that in group C in 16 weeks ( P < 0. 05 ). The + dp/dt in group A and group B was significantly lower than that of group C after the operation ( PP <0. 01) ,and the + dp/ dt in group A was increased,as compared with that before 16 weeks. The + dp/dt in group A and group B was obviously lower than that in group C after operation ( P <0. 01 ) ,and dp/dt in group A was significantly higher than that of group B ( P > 0. 05 ) . The BNP in group B was significantly higher than that in group C after operation ( P <0.01) ,and BNP in group A was obviously higher than that in group C at 12 weeks after operation ( P < 0. 01) , which was similar to that in group C at 16 weeks ( P >0. 05) ,however,which was significantly lower than that in group B(12 week; P <0.01 ;16 week; P <0.01). Conclusion The pinacidil can significantly improve the cardiac function of rat models of heart failure with chronic pressure overload.
关键词
大鼠/腹主动脉缩窄/动物模型/吡那地尔/心功能Key words
rats/abdominal aortic coarctation/animal model/pinacidil/cardiac function引用本文复制引用
出版年
2011
NETL
NSTL
维普
万方数据