Changes in CRP/Alb,PDGF and BUN/Cr levels in chronic heart failure patients and their prognostic value
Objective To investigate the changes in the levels of C-reactive protein to albumin ratio(CRP/Alb),platelet-derived growth factor(PDGF)and blood urea nitrogen to creatinine ratio(BUN/Cr)in patients with chronic heart failure(CHF),and to analyze their efficacy in predicting cardiovascular mortality and all-cause mortality.Methods A total of 109 CHF patients admitted to our hospital from January 2020 to March 2022 were selected.They were divided into death group(26 cases)and survival group(83 cases)according to cardiovascular death and all-cause mortality within 1 year.The sociodemographic data,clinical characteristics(New York Heart Association[NYHA]cardiac function classification,left ventricular ejection fraction[LVEF],left ventricular end-systolic diameter[LVESD],left ventricular end-diastolic diameter[LVEDD],N-terminal brain natriuretic peptide precursor[NT-proBNP],clinical medication),CRP/Alb,PDGF,and BUN/Cr levels were compared between the two groups.Cox regression was used to analyze influencing factors for the cardiovascular mortality and all-cause mortality.The receiver operating characteristic(ROC)curve was plotted to analyze the predictive value,and the Kaplan-Meier curve(K-M)survival curve was plotted to analyze the survival rate of CHF patients with different CRP/Alb,PDGF,and BUN/Cr levels.Results NYHA cardiac function classification,LVESD,LVEDD and NT-proBNP were significantly higher in the death group than those of the survival group,and LVEF was significantly lower(P<0.05).CRP/Alb,PDGF,and BUN/Cr were significantly higher in the death group than those of the survival group(P<0.05).CRP/Alb in CHF patients was positively correlated with PDGF and BUN/Cr,and PDGF was positively correlated with BUN/Cr(P<0.05).After adjustment for confounding factors(e.g.,NYHA cardiac function class),CRP/Alb,PDGF,and BUN/Cr were still influencing factors for cardiovascular death and all-cause mortality in CHF patients(P<0.05).The area under the curve(AUC)CRP/Alb,PDGF,BUN/Cr and their combination in predicting cardiovascular death and all-cause death was 0.712,0.801,0.738,and 0.911,respectively(P<0.05).CHF patients with high levels of CRP/Alb,PDGF,and BUN/Cr had a significantly lower survival than those with low levels(P<0.05).Conclusion CRP/Alb,PDGF,and BUN/Cr are correlated with cardiovascular mortality and all-cause mortality in CHF patients,and their combination detection can be used to predict the outcome of CHF,thus providing references for assessing the prognosis and treatment.
C-reactive protein to albumin ratio(CRP/Alb)platelet-derived growth factor(PDGF)blood urea nitrogen to creatinine ratio(BUN/Cr)chronic heart failurecardiovascular mortalityall-cause mortality
万方数据
维普
