Correlation analysis of blood fibrinogen,troponin I,troponin T and lipoprotein associated phospholipase A2 with the prognosis of acute myocardial infarction
Objective To analyze the correlation of fibrinogen(Fib),troponin I(TNI),troponin T(TnT)and lipoprotein associated phospholipase A2(Lp-PLA2)with the prognosis of acute myocardial infarction(AMI).Methods A total of 122 AMI patients who were diagnosed and treated from 2020 to 2021 were selected as the study group.According to the presence or absence of adverse cardiovascular events(MACEs)at 3 months after admission,AMI patients were divided into poor prognosis group(n= 39)and good prognosis group(n= 83).During the same period,40 healthy volunteers were selected as the control group.Blood FIB,TNI,TnT and Lp-PLA2 levels between the study group and the control group,and between the poor prognosis group and the good prognosis group were compared.Their predictive value for the poor prognosis of AMI patients was explored.Results The blood FIB,TNI,TnT and Lp-PLA2 levels in the study group were significantly higher than those in the control group(P<0.05),which were significantly higher in the poor prognosis group than those in the good prognosis group(P<0.05).The receiver operating characteristic(ROC)curves showed that the area under the curve(AUC)of FIB,TNI,TnT,Lp-PLA2 and their combination detection to predict the poor prognosis of AMI patients was 0.826(sensitivity=56.4%and specificity= 100%),0.816(sensitivity= 51.3%and specificity= 100%),0.878(sensitivity= 51.3%and specificity=100%),0.947(sensitivity=76.9%and specificity=84.3%)and 0.947(sensitivity=82.1%and specificity=100%),respectively.Conclusion Blood FIB,TNI,TnT and Lp-PLA2 are highly expressed in AMI patients,which are significantly higher in those with a poor prognosis.Their combination detection offers a high predictive value for the poor prognosis of AMI patients.
万方数据
维普
